https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 High-fat Diet Alters Male Seminal Plasma Composition to Impair Female Immune Adaptation for Pregnancy in Mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46022 300 inflammatory genes were similarly regulated in the uterine endometrium by mating independently of paternal diet, and 13 were dysregulated by HFD-fed compared with CD-fed males. Seminal vesicle fluid factors reduced in HFD-fed males, including TGF-β1, IL-10, and TNF, were among the predicted upstream regulators of differentially regulated genes. Additionally, the T-cell response induced by mating with CD-fed males was blunted after mating with HFD-fed males, with 27% fewer CD4+ T cells, 26% fewer FOXP3+CD4+ regulatory T cells (Treg) cells, and 19% fewer CTLA4+ Treg cells, particularly within the NRP1+ thymic Treg cell population. These findings demonstrate that an obesogenic HFD alters the composition of seminal vesicle fluid and impairs seminal plasma capacity to elicit a favorable pro-tolerogenic immune response in females at conception.]]> Wed 09 Nov 2022 11:05:03 AEDT ]]> miRNA regulation of immune tolerance in early pregnancy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37560 Thu 18 Feb 2021 11:00:21 AEDT ]]> Roles of male reproductive tract extracellular vesicles in reproduction https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37679 Fri 12 Mar 2021 10:57:58 AEDT ]]> Thymus-derived regulatory T cells exhibit Foxp3 epigenetic modification and phenotype attenuation after mating in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37678 Fri 12 Mar 2021 10:43:52 AEDT ]]> Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37676 Fri 12 Mar 2021 10:15:52 AEDT ]]> TLR4 signaling is a major mediator of the female tract response to seminal fluid in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37674 Fri 12 Mar 2021 10:01:58 AEDT ]]>